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The good news is that there are a number of medications available for treatment of depression.

Selective serotonin reuptake inhibitors (SSRIs) are the drug of choice for treatment of patients with panic disorder.

When prescribing an antidepressant that's likely to work well for you, your doctor may consider: Certain brain chemicals called neurotransmitters are associated with depression — particularly serotonin (ser-o-TOE-nin), norepinephrine (nor-ep-ih-NEF-rin) and dopamine (DOE-puh-meen).

Most antidepressants relieve depression by affecting these neurotransmitters.

In order to answer this, let’s take a brief review of depression and the antidepressants currently available.

As you may know, depression is a mood disorder that causes a persistent feeling of sadness and loss of interest. Depression can lead to a variety of emotional and physical problems which can result in the inability to perform your normal day-to-day activities.

Effects on blood levels and bioavailability of coadministered drugs, as well as pharmacodynamic interactions, account for most clinically significant SSRI-drug interactions.

They have the advantage of ease of dosing and low toxicity in overdose.

Although antidepressants may not cure depression, they can reduce your symptoms. But if it doesn't relieve your symptoms, or it causes side effects that bother you, you may need to try another.

Most patients have a favorable response to SSRI therapy; however, 30 percent will not be able to tolerate these drugs or will have an unfavorable or incomplete response.

Strategies to improve management of such patients include optimizing SSRI dosing (starting at a low dose and slowly increasing the dose to reach the target dose) and ensuring an adequate trial before switching to a different drug.

SSRIs are metabolized via the cytochrome P-450 system and may have drug interactions on that basis.

The degree of enzyme inhibition varies among SSRIs.

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